Absolute and Relative Grip Strength as Predictors of Cancer: Prospective Cohort Study of 445,552 UK Biobank Participants

J Cachexia Sarcopenia Muscle. December 24, 2021. doi: 10.1002 / jcsm.12863. Online ahead of print.


BACKGROUND: Reduced muscle strength, as measured by absolute grip strength, has been associated with an increased risk of certain site-specific cancers. The ability of grip strength to predict other diseases may be affected depending on whether it is expressed in absolute or relative terms, but evidence for cancer is scarce. This study compared the associations of absolute and relative grip strength with all causes and 15 site-specific cancers.

METHODS: A prospective cohort study was undertaken using data from UK Biobank. The exposure variable was grip strength, in absolute value (kilograms) and relative to weight, body mass index (BMI), height. and body fat. The result was incident cancer, at 15 sites and overall. Cox proportional hazards models were performed to study the associations.

RESULTS: This study included 445,552 participants, of which 53.8% were female, with a mean age (SD) of 56.3 (8.11) years. During a median follow-up period of 8.8 years, 48,886 (11.0%) patients were diagnosed with cancer. After adjusting for socio-demographic and lifestyle factors, as well as several tests, absolute grip strength was inversely and linearly associated with the endometrium. [hazard ratio (HR): 0.74, 95% confidence interval (CI): 0.69; 0.79, P value <0.001], gallbladder (HR: 0.81, 95% CI: 0.72, 0.92, P value = 0.001), liver (HR: 0.86, 95% CI: 0.79, 0.93, P-value

CONCLUSIONS: Grip strength was associated with the risk of several site-specific cancers and all-cause cancer. Head and neck and breast cancers may be better predicted by relative grip strength.

PMID: 34953058 | DOI: 10.1002 / jcsm.12863

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