GGT/HDL-c ratio linked to the development of diabetes | Latest news for doctors, nurses and pharmacists

The ratio of gamma-glutamyl transferase (GGT) to high-density lipoprotein cholesterol (HDL-c) shares a positive, nonlinear relationship with incident diabetes, reports a recent Japanese study.

The researchers conducted a retrospective cohort analysis of 15,171 patients (mean age 43.69 years, 53.75% male), in whom the GGT/HDL-c ratio was determined by blood test after an overnight young. Incident diabetes was defined as blood glucose ≥ 7 mmol/L, glycated hemoglobin ≥ 6.5%, or self-reported diagnoses.

During a median follow-up of 64.9 months, 350 patients developed diabetes, an incidence rate of 3.77 per 1,000 person-years.

A multivariate analysis, fully adjusted for potential confounders, showed that each additional unit of GGT/HDL-c ratio resulted in a 1.3% increased risk of incident diabetes (relative risk [HR]1.013, 95% confidence interval [CI]1.002–1.024).

By applying a penalized spline method to the Cox proportional hazards regression model, the researchers also found that diabetes risk shared a nonlinear relationship with the log-transformed GGT/HDL-c ratio, with an inflection point at the ratio value 6.477.

HR estimates were 2.568 (95% CI, 1.157 to 5.699) and 1.012 (95% CI, 1.001 to 1.023) on the left and right sides of the inflection point, respectively.

“When the GGT/HDL-c ratio is less than 6.477, there is a significant positive association with the risk of diabetes. The result should provide a benchmark for clinical monitoring of the GGT/HDL-c ratio,” the researchers said.

“When the level of the GGT/HDL-c ratio is below the inflection point, lowering the level of the GGT/HDL-c ratio can significantly reduce the risk of developing diabetes in the future,” they added. .

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