Liver enzymes mediate the association of fine particulate exposure with diabetes risk | Latest news for doctors, nurses and pharmacists
Liver enzymes play a partial role in the relationship between particulate matter (PM) exposure and diabetes risk, indicating the involvement of lipid accumulation, oxidative stress and chronic liver inflammation in its pathogenesis , reports a recent study.
“Although liver-derived biological intermediates may play an irreplaceable role in the pathophysiology of diabetes, few studies have explored this in the association between PM and diabetes,” the researchers said.
This study included a total of 7,963 participants from the China Multi-Ethnic Cohort. A group of researchers assessed residential exposure to particles using a validated spatio-temporal assessment method. The American Diabetes Association criteria were used to diagnose diabetes.
Multivariate regression models were used to explore associations between PM, liver enzyme (alanine aminotransferase [ALT]aspartate aminotransferase, alkaline phosphatase and γ-glutamyl transpeptidase [GGT]) and diabetes. Finally, a mediation analysis was conducted to determine the role of liver enzymes in the relationship between PM and diabetes.
Exposure to PM showed a positive association with the onset of diabetes (odds ratio [OR] for each 10-μg/m3 increment in ≤1 μm PM [PM1]1.32, 95% confidence interval [CI], 0.83‒2.09; OR in ≤2.5 μm (PM2.5), 1.33, 95% CI, 1.07‒1.65; OR in ≤10 μm (PMten), 1.18, 95% CI, 1.02‒1.36).
Of note, ALT (4.47%) and GGT (4.78%) appeared to significantly facilitate the association between PM2.5 and diabetes, while ALT (4.30%) showed a mediating role on PMten. However, none of these liver enzymes showed any significant mediating effect on PM1.