Low Antithrombin Levels Linked to ECMO Ventilation in COVID-19 Patients | Latest news for doctors, nurses and pharmacists

Low levels of antithrombin on admission to the intensive care unit (ICU) appear to increase the need for extracorporeal membrane oxygenation (ECMO) in patients with
COVID-19[feminine]reports a recent study.

Researchers conducted a retrospective study of 66 consecutive COVID-19 patients who were admitted to intensive care. The objective of the study was to identify predictors of mechanical ventilation (MV) and ECMO.

Logistic regression revealed that advanced age was an important risk factor for CF (odds ratio [OR]1.04, 95% confidence interval [CI], 1.00–1.08; p=0.03), as well as the sequential assessment of organ failure scores (OR, 1.53, 95% CI, 1.18-1.97; p

Meanwhile, those who eventually needed ECMO had a significantly lower estimated glomerular filtration rate (OR, 0.98, 95% CI, 0.96 to 1.00; p=0.04) and antithrombin levels (OR, 0.94, 95% CI, 0.88 to 1.00; p=0.03) at ICU admission.

A fully adjusted analysis confirmed that lower antithrombin at ICU admission worsened the likelihood of needing ECMO (OR, 0.94, 95% CI, 0.88-1.00; p = 0.03).

“Early recognition of COVID-19 patients at high risk of exacerbation allows physicians to make appropriate clinical decisions, including the need for hospitalization, strict monitoring, and medications,” the researchers said. “Identifying high-risk patients will improve their outcomes and allow for more appropriate distribution of medical resources.”

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