Neutrophil-to-lymphocyte ratio predicts cancer outcome in locally advanced clear cell renal cell carcinoma

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Clin Génitourin Cancer. November 22, 2021: S1558-7673 (21) 00199-3. doi: 10.1016 / j.clgc.2021.10.009. Online ahead of print.


BACKGROUND: To assess the association of neutrophil-to-lymphocyte ratio (NLR) with recurrence-free survival (RFS) and overall survival (OS) in patients with locally advanced non-metastatic clear cell renal cell carcinoma (ccRCC) undergoing radical nephrectomy.

Material and methods: We retrospectively identified 880 nephrectomies performed between January 2009 and December 2016 in a single center, examined data from 478 radical nephrectomies for renal tumors and identified 187 patients with locally advanced non-metastatic ccRCC (pT3-T4 N0M0). The NLR was obtained preoperatively and calculated by dividing the absolute number of neutrophils by the absolute number of lymphocytes. OS and RFS were assessed by the Kaplan-Meier method. Cox proportional hazards regression models were used to assess predictors of RFS and OS.

RESULTS: Among 187 patients with ccRCC (mean age 63.4 ± 11.5 years; 118 [63.1%] male), the median follow-up was 48.7 months. In univariate analysis, in patients with Fuhrman nuclear differentiation grade 3-4, the median time to recurrence was significantly shorter with NLR ≥ 4 than

CONCLUSION: For patients with locally advanced and non-metastatic ccRCC, RFS was reduced with high nuclear differentiation grade and high preoperative NLR. These results suggest an association between higher NLR and poorer results in locally advanced ccRCCs.

PMID: 34969630 | DOI: 10.1016 / j.clgc.2021.10.009

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