Results of percutaneous thrombectomy in female and male patients with PE

According to the results of a study published in CHEST.

Although research has shown that female patients hospitalized for PE have poorer outcomes than male patients, evidence is lacking on gender-based differences in outcomes associated with interventional therapies for PE. The researchers therefore assessed the differences in outcomes between male and female patients with PE undergoing percutaneous thrombectomy.

The researchers conducted a retrospective cross-sectional study using national U.S. inpatient claims data collected between 2016 and 2018 on patients with a discharge diagnosis of PE who also underwent percutaneous thrombectomy. Data from a total of 5160 adult patients, including 2520 women and 2640 men, were included in the study. A multivariable regression model with patients as the categorical variable was used to assess the association between PE diagnosis and various outcomes, with in-hospital death being the primary outcome. The investigators’ analyzes also took into account demographic variables, comorbidities, discharge home, length of hospital stay and use of healthcare resources.


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Investigators found a higher incidence of various adverse outcomes in female patients compared to male patients, including more perioperative bleeding (16.9% vs. 11.2%; P <.05 more blood transfusions versus>P P <.05 in-hospital mortality was also higher for women than men versus respectively odds ratio adjusted ci>P =.003).

Length of stay and use of health care resources were found to be similar for men and women, although women were less likely than men to be sent home (47.9% versus 60, 3%, respectively, aOR 0.7, 95% CI 0.50-0.99; P =.04) and instead required additional ambulatory care.

Limitations of the study include the inability to assess the severity of PE; lack of pharmacotherapeutic details on anticoagulation; inability to distinguish between comorbidities and hospital complications; and missing data.

“Our data suggest that patients undergoing percutaneous pulmonary artery thrombectomy represent a particularly vulnerable patient population,” the researchers concluded. Further studies are needed to validate and determine the causes, they added.

Disclosure: Some study authors have disclosed affiliations with biotechnology, pharmaceutical and/or device companies. Please see the original citation for a full list of author disclosures.

Reference

Agarwal MA, Dhaliwal JS, Yang EH, et al. Gender differences in outcome of percutaneous pulmonary artery thrombectomy in patients with pulmonary embolism. Chest. Published online August 1, 2022. doi:10.1016/j.chest.2022.07.020

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