Second-hand smoke during the first trimester increases the risk of coronary artery disease in infants | Latest news for doctors, nurses and pharmacists

Mothers exposed to environmental tobacco smoke (ETS) during the first trimester of pregnancy are more likely to give birth to infants with congenital heart defects (CHD), according to a recent study.

The researchers conducted a case-control analysis of 749 fetuses with coronary artery disease and 880 fetuses without. Logistic regression analysis revealed that exposure to ETS from 12 months before pregnancy through the first trimester increased the risk of coronary heart disease by almost 70% (adjusted odds ratio [OR]1.67, 95% confidence interval [CI]1.28–2.18).

Such ETS exposure patterns increased the odds of septal abnormalities (adjusted OR, 1.58, 95% CI, 1.18 to 2.12), conotruncal abnormalities (adjusted OR, 1.86, 95% CI, 1.21 to 2.84), left ventricular outflow tract obstructions (adjusted OR, 1.69, 95% CI, 1.15 to 2.48), left ventricular outflow tract obstructions right ventricular outflow tract (adjusted OR, 1.82, 95% CI, 1.25 to 2.67) and other types of coronary artery disease (adjusted OR, 2.73, 95% CI, 1, 65 at 4.51).

Of note, exposure to ETS had a dose-response effect on the risk of coronary artery disease in the offspring. Exposure levels less than 1 hour per day did not affect the likelihood of developing coronary artery disease, but exposure for 1–2 hours per day (adjusted OR, 1.60, 95% CI, 1.07 to 2.41) and ≥ 2 hours per day (adjusted OR, 4.94, 95% CI, 2.43 to 10.05) increased this risk.

“These findings underscore the importance of preplanned pregnancy and prevention, including folic acid supplementation, paternal smoking cessation, maternal avoidance of ETS and harmful harmful substances at home or on the premises. work,” the researchers said.

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